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OralTop-300 Orally Dissolving Film making casting manufacturing machine
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LTPM CHINA 2nd Floor,Dongxin Road and 5th Development Road ,Caizhai Industrial Zone, Ruian City, Zhejing Province ,China

OralTop-300 Orally Dissolving Film making casting manufacturing machine

OralTop-300 Orally Dissolving Film making casting manufacturing machine

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Product description

Brief Introduction:

OralTop-Series Oral Thin Film making machine is specially designed and manufactured for making medicine film on paper, plastic film, metal film,etc. The active ingredient can be either dissolved or suspended in the polymeric matrix. OralTop-Series is used for making roll type Oral Thin Film.

Oral Thin Films with systemic activity for rapid delivery.An Oral Thin Film (OTF) is a very thin film, composed of a mono or multi-layer polymeric matrix, which is applied in the mouth. OTF are often water based soluble polymers designed to rapidly deliver drugs systematically. Depending on the drug candidate and the targeted indication, OTF can be formulated either as:

1.Orodispersible films working like conventional orodispersible tablets. In this case OTF dissolves within seconds in the mouth and the drug substance is swallowed together with the saliva and takes the same route as a tablet.

2.Or as a transmucosal film, where the active substance directly enters the systemic circulation via the buccal mucosa, avoiding the hepatic first pass effect.

The OTF dosage form presents several advantages, among which:

1.An easy drug intake therefore high acceptance by young and old patient thanks no swallowing difficulties and no beverages requirement for intake.

2.Flexible manufacturing with area proportional dosage (different doses from one base bulk).

3.Potential avoidance of the first-pass effect and improved bioavailability.

4.Innovative and appealing design offering more options for differentiating a product range.

Main Feature:

1.Coating thickness from 40 – 1000 microns wet.

2.High coating accuracy.

3.Individual temperature adjustment zones.

4.Recording of all process related parameters.

5.Variable speed of base film.

6.Uniform air flow throughout the machine.

7.cGMP Construction.

8.Liquid dosing system with peristaltic pump.

9.Thickness checking or wet & dry film.

Options

1.Products temperatures & film temperature measurement.

2.Recording of critical process data in 21 CFR part 11 certified software.

3.Report on excel file can be exported to USB to view on computer.

4.Equipment can be modified to make patch film of desired size and desired web length.

5.Cutting and Sitting line are a part of the complete processing line for oral strips.

6.Cutting line for cutting into small uniform strips & individual strip packing line.

7.Customer required designs and style / colors for printing.

8.Homogenizers and mixing tanks for integrations for a complete MDF suite.

9.Special style / shape for packing each film / multiple films.

Main Technical Data:

 

Item

Specification

Model

OralTop-300

Max.Production Width

300mm

Max. Line Speed

10m/min (depend on medicine)

Drying/Heating Method

Stainless Steel Heat Exchanger

Temperature Range

20-150

Total Power

18kw

Power Supply

380v 50hz three phase or 220v 50hz three phase

Overall Dimension

2700*1200*2300mm

Product Contact Parts Material

SS316L

Control System

PLC and Touch Screen control

Machine Frame Material

SUS304

Products:

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OralTop-300 Orally Dissolving Film making casting manufacturing machine

Product description
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Brief Introduction:

OralTop-Series Oral Thin Film making machine is specially designed and manufactured for making medicine film on paper, plastic film, metal film,etc. The active ingredient can be either dissolved or suspended in the polymeric matrix. OralTop-Series is used for making roll type Oral Thin Film.

Oral Thin Films with systemic activity for rapid delivery.An Oral Thin Film (OTF) is a very thin film, composed of a mono or multi-layer polymeric matrix, which is applied in the mouth. OTF are often water based soluble polymers designed to rapidly deliver drugs systematically. Depending on the drug candidate and the targeted indication, OTF can be formulated either as:

1.Orodispersible films working like conventional orodispersible tablets. In this case OTF dissolves within seconds in the mouth and the drug substance is swallowed together with the saliva and takes the same route as a tablet.

2.Or as a transmucosal film, where the active substance directly enters the systemic circulation via the buccal mucosa, avoiding the hepatic first pass effect.

The OTF dosage form presents several advantages, among which:

1.An easy drug intake therefore high acceptance by young and old patient thanks no swallowing difficulties and no beverages requirement for intake.

2.Flexible manufacturing with area proportional dosage (different doses from one base bulk).

3.Potential avoidance of the first-pass effect and improved bioavailability.

4.Innovative and appealing design offering more options for differentiating a product range.

Main Feature:

1.Coating thickness from 40 – 1000 microns wet.

2.High coating accuracy.

3.Individual temperature adjustment zones.

4.Recording of all process related parameters.

5.Variable speed of base film.

6.Uniform air flow throughout the machine.

7.cGMP Construction.

8.Liquid dosing system with peristaltic pump.

9.Thickness checking or wet & dry film.

Options

1.Products temperatures & film temperature measurement.

2.Recording of critical process data in 21 CFR part 11 certified software.

3.Report on excel file can be exported to USB to view on computer.

4.Equipment can be modified to make patch film of desired size and desired web length.

5.Cutting and Sitting line are a part of the complete processing line for oral strips.

6.Cutting line for cutting into small uniform strips & individual strip packing line.

7.Customer required designs and style / colors for printing.

8.Homogenizers and mixing tanks for integrations for a complete MDF suite.

9.Special style / shape for packing each film / multiple films.

Main Technical Data:

 

Item

Specification

Model

OralTop-300

Max.Production Width

300mm

Max. Line Speed

10m/min (depend on medicine)

Drying/Heating Method

Stainless Steel Heat Exchanger

Temperature Range

20-150

Total Power

18kw

Power Supply

380v 50hz three phase or 220v 50hz three phase

Overall Dimension

2700*1200*2300mm

Product Contact Parts Material

SS316L

Control System

PLC and Touch Screen control

Machine Frame Material

SUS304

Products:

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Add:LTPM CHINA 2nd Floor,Dongxin Road and 5th Development Road ,Caizhai Industrial Zone,  Ruian City, Zhejing Province ,China

Tel:86-0577-65158955    Fax: 86-0577-65158944
Business Phone : 86-0577-65158955
E-mail:info@chinaleadtop.com

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