2020/06/30

Belt dryer scope of application and selection

Use of belt dryer is very wide, present in the pharmaceutical, food, biological, chemical and other fields already have it handy. However, in each area of its selection criteria is not the same, because the requirements and parameters of the dried material in various fields have a greater difference. For example: in the pharmaceutical industry (especially medicine), extract viscosity are generally large, and drying temperature requirements more stringent, the melting point of control to be precise (especially polysaccharide material), the control range to meet the different degree of vacuum heating and temperature requirements of section to have online auto tuning function, and so on. Also to try to improve the detection system to comply with pharmaceutical GMP standards. The first step in selecting a vacuum belt dryer is the need for drying materials for sample test, which is very important. So for equipment suppliers whether it has a material testing equipment and experienced personnel sample is the most direct way to measure customer the manufacturer's capabilities. Qualified vacuum belt dryer manufacturer usually after the test material can in the shortest possible time to provide customers a comprising: actual evaporation material, dynamic drying vacuum, drying temperature distribution, mass size, actual drying time actual product specifications report production, energy consumption per unit of consumption ratio, enabling customers to choose according to requirements to meet production equipment models and specifications. Select vacuum belt dryer of the second step is a comprehensive study level of the manufacturer's design and manufacturing capabilities. In general, manufacturers will be on the basis of material to provide a test report on the preliminary technical design and program design detailed statement of reasons in accordance with the customer's production targets and working conditions. Technical design is assessed manufacturers manufacturing capacity vacuum belt dryer extremely important part, especially manufacturers of key technology and equipment design as described: design design vacuum system, heating system, correction system design, cleaning and feeding system design, system design and other materials. Another aspect of the manufacturing capacity is to examine the manufacturer's user's actual usage. Customers can according to the manufacturer's user list, requirements to the site visit, if the manufacturer does not generally have sufficient strength to reject the reasonable demands of customers, and some even provide targets for customers to choose more than one visit. And limited manufacturing capacity or a lower level of technology companies generally difficult to do this. The third step is to select a vacuum belt dryer is to investigate the actual processing capacity and production scale manufacturers. The vacuum belt dryer due to the large volume, auxiliary equipment and more high configuration requirements, the middle part of the complex, etc., to keep the equipment running for a long time to stabilize and easy.The price of this device is also more expensive, users are generally optimistic about its drying capacity and technical advantages of the use of huge amounts of money while purchasing, so are hoping to recover the cost as soon as possible to improve the economic efficiency of enterprises. Therefore, in the procurement of equipment be sure to choose the size, design and manufacture of practical experience and reliable service with the manufacturer to ensure that the system can be assured, of course, this provided by the manufacturer of vacuum belt dryer is generally slightly higher price point, but for users, the use of a sense of security, customers must not covet a moment because of low price and may affect the overall situation.

2020/06/30

Spray Drying In The Pharmaceutical Industry

Spray drying is one of the most remarkable technologies currently to be applied to pharmaceuticals. It is a continuous process that converts, in a single step,  a liquid feed into a powder and is an ideal process when precise attributes such as particle size, morphology and stability are required. This review describes  the technology, current and future applications and how the present level of understanding and modeling tools enable a process development stage that is  both lean and risk-free.

2020/06/30

Difference between dry granulation and wet granulation-victor granulator?

Wet Granulation: The process of adding a liquid solution to powders involves the massing of a mix of dry primary powder particles using a granulating fluid. The fluid contains a solvent that must be volatile, so that it can be removed by drying, and be non-toxic. Typical liquids include water, ethanol and isopropanol, either alone or in combination. The liquid solution can be either aqueous-based (safer) or solvent-based. Water mixed into the powders can form bonds between powder particles that are strong enough to lock them together. However, once the water dries, the powders may fall apart. Therefore, water may not be strong enough to create and hold a bond. In such instances, a liquid solution that includes a binder is required. Once the solvent/water has been dried and the powders have formed a more densely held mass, then the granulation is milled. The process can be very simple or very complex depending on the characteristics of the powders and the available equipment. In the traditional wet granulation method, the wet mass is forced through a sieve to produce wet granules that are subsequently dried. A subsequent screening stage breaks agglomerates of granules. Organic solvents are used when water-sensitive drugs are processed, as an alternative to dry granulation, or when a rapid drying time is required. Because direct compressing is not the best technology for many active substances, wet granulation is still a preferred method. Even if the active substance is sensitive to hydrolysis, modern equipment (a fluidized bed, for example) eliminates all problems in wet granulation. Dry Granulation: This process is used to form granules without using a liquid solution, because the product to be granulated may be sensitive to moisture and heat or does not compress well. Forming granules without moisture involves compacting and size reduction of the mix to produce a granular, free flowing blend of uniform size. Thus, the primary powder particles are aggregated under high pressure using swaying or high shear mixer-granulators. Dry granulation can be done in two ways: either a large tablet (slug) is produced in a heavy duty tableting press or the powder is squeezed between two rollers to produce a sheet of materials (roller compactor/chilsonator). When a tablet press is used for dry granulation, the powders may not possess enough natural flow to feed the product uniformly into the die cavity, resulting in varying degrees of densification. The double roller granulator (granulator-compactor) uses an auger-feed system that will consistently deliver powder uniformly between two pressure rollers. The powders are compacted into a ribbon or small pellets between these rollers and milled through a low-shear mill. When the product is compacted properly, it can then be passed through a mill and final blend before tablet compression. Finally, wet granulation involves the production of a granule by the addition of liquid binders to the powder mixture. Both continuous direct compression (CDC) and continuous mixing for the dry granulation processes involve the individual loading and accurate feeding of the API and a variety of excipients to a continuous blender

2020/06/30

IMPORTANCE OF MIXING

Mixing is at the heart of most production systems in the chemical process industry, pharmaceutical industry, food industry, and allied industries. It is of vital importance in processing solids, liquids, and gases in the polymer, glass, ceramics, building materials, pulp and paper, petroleum, and power industries and in industrial waste treatment systems. By definition, mixing is the process of thoroughly combining different materials to produce a homogeneous product. The resulting mixture in most cases is a combination of dissimilar materials. In some cases, a chemically homogeneous material may be mixed to produce a uniform blend of a desired weight or volume with consistent particle-size distribution, colour, texture, or other required attributes. Mixing is a critical process because the quality of the final product and its attributes are derived from the quality of the mix. Improper mixing results in a non-homogeneous product that lacks consistency with respect to desired attributes such as chemical composition, colour, texture, flavor, reactivity, and particle size. The wide variety and ever-increasing complexity of mixing processes encountered in industrial applications requires careful selection, design, and scale-up to ensure effective and efficient mixing. Improved mixing efficiency leads to shorter batch cycle times and operational costs. Today’s competitive production systems necessitate robust equipment that are capable of faster blend times, lower power consumption, and adaptability of equipment for use with multiple products. Moreover, in addition to carrying out mixing operations, many modern mixers are designed to combine different processing steps in a single piece of equipment: for example, coating, granulation, heat transfer, and drying. A mixer is no longer a generic production tool, but a critical and decisive business tool. This is because profitability and competitive advantage are dependent on subtle improvements in product quality through gains in mixing performance and efficiency. Good mixing is imperative for minimizing investment and operating costs providing high yields, and thereby enhancing profitability.

2020/06/30

​Universal Crusher Should Be Operated Correctly To Avoid Blockage

Guide: The crusher industry is still a new industry in China, which belongs to the initial stage of development. However, from the experience of a few decades, the speed is relatively fast, especially the universal crusher. Its application field is expanding continuously, and it is suitable for pharmaceutical, chemical, metallurgical, food, construction and other industries. It is known that the universal crusher adopts the impact crushing method. When the material enters the crushing chamber, it is impacted by six moving hammers which rotate at high speed. The crushed material is crushed by collision between the gear ring and the material. With the help of the air flow, the crushed material enters the crushing bag through the sieve hole, leaving no residue. The utility model has the advantages of high efficiency, low noise, reliable working performance and product quality, safe operation, low drug hygiene and consumption, etc. In recent years, with the improvement of technology, the omnipotent Chinese medicine crusher has simple structure, strong, stable operation and good crushing effect. All the inner walls of the shell have been machined to achieve smooth surface, which has changed the phenomenon of rough inner walls and powder accumulation of previous models, and made the production of drugs, food and chemical products more in line with national standards and meet the requirements of GMP.

2020/06/30

What are CGMPs? Why are CGMPs so important?

What are CGMPs? CGMP refers to the Current Good Manufacturing Practice regulations enforced by the FDA. CGMPs provide for systems that assure proper design, monitoring, and control of manufacturing processes and facilities. Adherence to the CGMP regulations assures the identity, strength, quality, and purity of drug products by requiring that manufacturers of medications adequately control manufacturing operations. This includes establishing strong quality management systems, obtaining appropriate quality raw materials, establishing robust operating procedures, detecting and investigating product quality deviations, and maintaining reliable testing laboratories. This formal system of controls at a pharmaceutical company, if adequately put into practice, helps to prevent instances of contamination, mix-ups, deviations, failures, and errors. This assures that drug products meet their quality standards. The CGMP requirements were established to be flexible in order to allow each manufacturer to decide individually how to best implement the necessary controls by using scientifically sound design, processing methods, and testing procedures. The flexibility in these regulations allows companies to use modern technologies and innovative approaches to achieve higher quality through continual improvement. Accordingly, the "C" in CGMP stands for "current," requiring companies to use technologies and systems that are up-to-date in order to comply with the regulations. Systems and equipment that may have been "top-of-the-line" to prevent contamination, mix-ups, and errors 10 or 20 years ago may be less than adequate by today's standards. It is important to note that CGMPs are minimum requirements. Many pharmaceutical manufacturers are already implementing comprehensive, modern quality systems and risk management approaches that exceed these minimum standards. Why are CGMPs so important? A consumer usually cannot detect (through smell, touch, or sight) that a drug product is safe or if it will work. While CGMPs require testing, testing alone is not adequate to ensure quality. In most instances testing is done on a small sample of a batch (for example, a drug manufacturer may test 100 tablets from a batch that contains 2 million tablets), so that most of the batch can be used for patients rather than destroyed by testing. Therefore, it is important that drugs are manufactured under conditions and practices required by the CGMP regulations to assure that quality is built into the design and manufacturing process at every step. Facilities that are in good condition, equipment that is properly maintained and calibrated, employees who are qualified and fully trained, and processes that are reliable and reproducible, are a few examples of how CGMP requirements help to assure the safety and efficacy of drug products.

2020/06/30

Do You Know That The Invention Of The Capsule Is Actually Because Of This？

Over the years, the growth of the pharmaceutical industry has also driven the development and evolution of capsules as a medicine delivery method. By allowing patients to take medicine orally has made this field of medical treatment much less invasive than giving subjects needles and/or suppositories, thereby making capsules a highly popular option among the general public. Wondering how this vehicle came about in the first place? This article will uncover secret history of capsules, revealing the pioneers behind this important invention in modern medicine, from a primitive empty capsule filling machine to modern capsule filling devices like the ProFiller system.

2020/06/30

Method For Preparing Spongy Graphene By Freeze Dryer

Graphene is a honeycomb two-dimensional lattice structure lamellar nano-material formed by closely mixing carbon atoms in sp2 hybrid mode. Since its discovery in 2004, graphene has attracted the attention of researchers with its excellent physical and chemical properties. It has rapidly become a research hotspot in the fields of physical chemistry, material energy, life sciences and information technology. Graphene's special monoatomic layered structure gives it a very large specific surface area, and sp2 hybridization gives it many wonderful properties and excellent physicochemical properties. In terms of mechanical properties, it has high strength and high modulus; in thermal properties, it has high thermal conductivity; in terms of electrical properties, it has high electrical conductivity. In addition, Graphene has some special properties, such as: Graphene has quantum Hall effect and ferromagnetism at room temperature. Since the discovery of graphene, scientific researchers have been trying to prepare graphene by different methods. At present, according to the principle of preparation, it can be divided into physical methods and chemical methods. The physical method, that is, the method of mechanical peeling, can be further divided into a micro mechanical peeling method and a solvent peeling method. The chemical methods mainly include a graphite oxide reduction method, a thermal decomposition SiC method, and a chemical vapor deposition (CVD) method.