2020/06/30

Daily Maintenance Skills Of Tablet Press Machine Mould In Pharmaceutical Field

Tablet press belongs to a kind of pharmaceutical processing equipment, which is suitable for tablet pharmaceutical tablet forming. In the process of tablet pharmaceutical production, tablet press mold plays an important role in the quality of products. For example, the punch hole of the rotary tablet press becomes larger, resulting in uneven punching packing, resulting in non-compliance of the product weight difference or cracks; the length of the punch body varies, directly affecting the product weight difference and hardness, resulting in cracks, or affecting the brittleness; the punch has edge gouging, curling or uneven punch, resulting in one-sided cracks, stick punching, etc. Therefore, before using the die, we need to pay attention to inspection and necessary maintenance or replacement to ensure the stability of product quality and continuous tablet production, and reduce the cost of the enterprise. In addition, it is necessary to check and maintain the die of powder tablet press after installation and use, so as to ensure that the equipment is in good condition when the next enterprise uses it. Therefore, in the daily management, the operator must pay attention to the daily maintenance, maintenance and storage of the tablet press mold to ensure the quality of the products. In this regard, there are tablet press equipment manufacturers to share the daily maintenance and service skills of the tablet press mold, mainly divided into five points, for industry reference only. First, if the pharmaceutical manufacturing enterprise newly purchases the full-automatic tablet press mould, it is necessary to let the tablet press mould be received and accepted by the workshop mechanic, and then it will be handed over to the tablet pressing team leader for re confirmation. Under the condition of ensuring stable operation of the equipment, it can be put into production.

2020/06/30

Structure Of Automatic Capsule Filling Machine

The fully automatic capsule filling machine consists of an empty capsule discharge device, a capsule distribution device, a powder discharge device, a metering plate mechanism, a capsule filling and sealing mechanism, a box main drive mechanism, and an electrical electrical control system. 1, empty capsule discharge device: composed of hoppers and transmission lines, the main storage of empty capsules and empty capsules one by one vertical into the capsule division device. 2.The capsule distribution device: Enables the empty capsule to enter the selection fork of the distribution device, and the selection of the fork to move down will send the next six capsules at a time, and the rubber cap will be on it. At the same time, the vacuum separation system passes the capsule into the module and separates the body cap. 3, powder discharge device: consists of powder bucket, powder bucket screw, down material transport Guandeng, mainly under the screw and stirring effect of the stored powder has control into the metering plate. 4, measuring plate mechanism: according to the capsule specifications and the amount of the matching measuring plate specifications. Powder in the intermittent rotation of the measuring plate through five times filled compacted into the column, and pushed into the next module of the capsule. 5, capsule filling and sealing mechanism: When pushed into the capsule body under the drug column capsule, the upper and lower modules of the rubber cap and the lower capsule body push up to buckle it.

2020/06/30

Hemp Extraction Turning Out To Be A Huge Growth Opportunity For Cannabis Companies

It may be the hottest portion of the hottest market in 2019. But such a demand also creates questions about is there enough supply to meet that demand of basic resources especially the extractors; the ones who extract the CBD from its various sources. Some observers even predict that there won't be enough supply to meet the demand for cannabis in oil form. But as one article said: "business is booming for cannabis extraction companies, despite the supply shortages." Some of the bigger well known cannabis companies have built or are building their own extraction facilities to complement their growth operations, but experts say that that infrastructure won't fill the future demand for cannabis oil products. Active Healthcare companies in the markets this week include: Sugarmade, Inc. (OTCQB:SGMD), Hemp Inc. (OTCPK: HEMP), Puration, Inc. (OTCPK: PURA), Terra Tech Corp. (OTCQX: TRTC), Village Farms International, Inc. (NASDAQ: VFF) (TSX: VFF.TO). Some writers believe that as the cannabis industry evolves, it will become fragmented, with various companies specializing in separate parts of the vertical market… just like other verticals in other industry markets. They predict that companies focusing solely on cannabis extraction will end up being an increasingly important subsection of the overall industry. Sugarmade, Inc. (OTCQB:SGMD) BREAKING NEWS: Sugarmade, a leading provider of hydroponic and other supplies to the agricultural and hemp sectors, today announces a new business initiative, which is expected the expand the Company' revenue base. Over the coming weeks, the Company will be entering the market for hemp extraction equipment and technologies, including several Chinese proprietary technologies, which hold the promise of increasing extraction efficiencies. "Our staff has done extensive research into the fast growing hemp industry. We continue to see an imbalance between cultivation outputs and extraction capacities within the industry. This leads us to believe the market for extraction services and the equipment required by these extraction companies will continue to accelerate. We plan to not only market several domestic technologies, but also next generation technologies we plan to important from Southern China, were hemp cultivation and herbal extraction technologies are well ahead of North America," commented Jimmy Chan, CEO of Sugarmade. According to the U.S. Department of Agriculture, farm production within the United States is expected to fall an additional 6.7% this year on top of already weak market over the past few years. These reductions will likely result in the overall U.S. agricultural production for 2019 being the lowest sice 2006. Prices for the commodities that are being produced are also at near record levels. One of the few bright spots in the agricultural sector is industrial hemp, which became legal via the December passage of the U.S. Farm bill. Estimates for hemp production for the 2019 season continue to be revised upward, with major hemp producing states, such as Colorado, Kentucky, Oregon, North Dakota, and others, reporting sharp increases in both cultivation applications and expected acreages. Arcview Market Research, is now predicting the market for Cannabidiol (CBD), which is mainly derived from hemp, will surpass $20 billion by year 2020. Hemp and its by products are growing fast and are one of the few bright spots in the agricultural sector. Mr. Chan continued, "It is clear the 2019 and 2020 hemp cultivation seasons will be massive. We expect the power balance between cultivators and extractors to continue to heavily favor extractors and we are seeing that part of the industry expand massively to be able to handle the significant amounts of hemp biomass that will be harvested and will ultimately be processed. We are planning to launch an effort to distribute not only legacy extraction equipment to extraction companies, but we also plan to begin distribution of next generation extraction technologies developed in the Chinese providence of Yunnan where the hemp industry has existed for more than a thousand years." Read this and more news for Sugarmade at: https://www.financialnewsmedia.com/news-sgmd/

2020/06/30

Introduction To Solid Preparations-Tablets

Introduction Tablets are solid dosage forms usually containing active pharmaceutical ingredient and excipients in powder, crystalline or granular form with or without diluents which is prepared either by moulding or compression process. They are solid, biconvex or flat in shape and vary in size, shape and weight which is depends on the medicaments which are used for preparation. They are also varying in hardness, disintegration; dissolution characteristics and thickness depend on their intended use and method of manufacture. Tablets are the most widely used solid dosage forms because of their advantages and popularity increasing day by day. Tablet usually contains filler, diluents, binders, lubricants, glidants, disintegrants, antiadherent, colouring agents and flavouring agents as excipients. Advantages of tablets Unit dosage forms with accurate, stable dose and great precision and least variability. Most stable with respect to physical, chemical and microbiological attributes. Cheapest oral dosage form, easy to handle, use and carry out with attractive and elegant appearance. Cheap, easy to swallow and production does not require and additional processing steps. Provide protection of medicaments from atmospheric conditions like air, moisture and light, etc. Provide prolonged stability to medicaments.

2020/06/30

The Future Of Anaerobic Granulation

Anaerobic treatment is well over 100 years old. Its initial development was for the treatment of domestic wastewaters, it then progressed in application to separate sludge digestion, then to treatment of dilute industrial waste-waters. Several processes have been developed that accomplish efficient treatment of wastewaters at short detention times. The anaerobic granulation system has been known for its unique ability to convert highly objectionable wastes into useful products. With global concerns over energy shortages and greenhouse gas formation through combustion of fossil fuels, more efforts towards renewable energy supplies is clearly needed. Greater efforts are now needed for broader applications of anaerobic granulation system for ridding the environment of unwanted organic materials by converting them into methane, a renewable energy source. The anaerobic granulation process leading towards efficient methane production from wastewaters clearly fits this need. Research towards even broader application is clearly of importance. Problems that need addressing are process reliability, toxicity causes and effects, odor production and control, and better understanding of refractory organic degradation. From all the numerous and the latest published research on anaerobic processes, cited in the earlier section, it is arguably the most promising wastewater treatment system that is able to meet the desired stringent criteria for future technology in environmentally sustainable development. Anaerobic granulation process would be the one that is able to minimize environmental harm while increasing industrial productivity and improving quality of life. At the moment, the most popular treatment process is the UASB reactor. However, with the recent development of EGSB and "Staged Multi-Phase Anaerobic" (SMPA) reactor systems, this may lead to a very promising new generations of anaerobic treatment system (Lettinga et al., 1997). These concepts behind the EGSB will provide a higher efficiency at higher loading rates, are applicable for extreme environmental conditions (e.g. low and high temperatures) and to inhibitory compounds. Moreover, by integrating the anaerobic process with other biological methods (sulfate reduction, micro-aerophilic organisms) and with physical-chemical methods, a complete treatment of the wastewater can be accomplished at very low costs, while at the same time valuable components can be recovered for reuse.

2020/06/30

What Is A Freeze Dryer? How Does It Work?

Freeze dryer and lyophilizer are synonymous names for the same equipment. A freeze dryer executes a water removal process typically used to preserve perishable materials, to extend shelf life or make the material more convenient for transport. Freeze dryers work by freezing the material, then reducing the pressure and adding heat to allow the frozen water in the material to sublimate. A Freeze Dryer’s 3 Primary Stages A freeze dryer works in three phases, with the first and most critical being the freezing phase. Proper freeze drying can reduce drying times by 30%. Freezing Phase Freeze dryers use various methods to freeze the product. Freezing can be done in a freezer, a chilled bath (shell freezer), or on a shelf in the freeze dryer. The freeze dryer cools the material below its triple point to ensure that sublimation, rather than melting, will occur. This preserves the material’s physical form. A freeze dryer most easily freeze dries large ice crystals, which can be produced by slow freezing or annealing. However, with biological materials, when crystals are too large they may break the cell walls, and that leads to less-than-ideal freeze drying results. To prevent this, the freezing is done rapidly. For materials that tend to precipitate, annealing can be used. This process involves fast freezing, then raising the product temperature to allow the crystals to grow. Primary Drying (Sublimation) Phase A freeze dryer’s second phase is primary drying (sublimation), in which the pressure is lowered and heat is added to the material in order for the water to sublimate. The freeze dryer’s vacuum speeds sublimation. The freeze dryer’s cold condenser provides a surface for the water vapor to adhere and solidify. The condenser also protects the vacuum pump from the water vapor. About 95% of the water in the material is removed in this phase. Primary drying can be a slow process. Too much heat can alter the structure of the material. Secondary Drying (Adsorption) Phase A freeze dryer’s final phase is secondary drying (adsorption), during which the ionically-bound water molecules are removed. By raising the temperature higher than in the primary drying phase, the bonds are broken between the material and the water molecules. Freeze dried materials retain a porous structure. After the freeze dryer completes its process, the vacuum can be broken with an inert gas before the material is sealed. Most materials can be dried to 1-5% residual moisture.

2020/06/30

FLUID BED DRYER USES AND APPLICATIONS

Fluid bed dryers. The average consumer has most likely never even heard of them. But in the world of bulk processing, fluid bed dryers have established themselves as dependable and multi-functional processors; capable of completing a variety of critical tasks. Fluid Bed Dryer Uses and Applications General Kinematics Valve Fluid bed dryers, as their name suggests, are used for drying materials such as granules, tablets, powders, fertilizers, and plastics. They are particularly popular in production industries like: l Chemical l Pharmaceutical l Food l Dairy l Metallurgical l Dyes l Other process industries Fluid bed dryers work on the principle of fluidization, a process in which hot gas or air is introduced into the spaces between solid particles. Upward forces on the particles increase as the air’s velocity increases causing them to equal the gravitational forces below. A state of fluidization now exists as the particles are suspended in what appears to be a boiling bed of liquid. Each particle is in direct contact with, and surrounded by, the hot gas or air – creating an efficient and uniform drying process.

2020/06/30

Film Coating Process In The Pharmaceutical Industry

The coating process is important step in the manufacture of modern pharmaceutical tablets. The coating itself can serve several functions – it can strengthen the tablet, control the release of active ingredients, improve its taste, provide colour, make it easier to package and handle, and protect it from moisture. Sugar coating was one of the earliest methods developed to coat tablets and is still practised for some products, especially confectionery. Other methods include fluidized bed coating, dry coating, but the most widely used method in the pharmaceutical and nutraceutical industry today is that of film coating. This article describes the essential process steps and equipment required for film coating tablets. Basic Film Coating Equipment At the heart of a modern film coating facility is the coating pan or drum and a spraying system. Also, required is an air handling unit and dust collector, and the associated controls. Depending on the application, a humidifier or dehumidifier may also be necessary. The modern coating pan is usually a perforated rotating drum that is housed within a cabinet. The cabinet provides the means of controlling the environment within the drum i.e., temperature and pressure, air flow rate and rotational speed of the drum. The film coating process begins with the loading of a batch of tablets into the coating drum. These are heated in a stream of flowing air and time allowed for dust to settle and a steady temperature of the outlet air to be reached (typically 40 to 46°C). This usually takes about 15 minutes. Spray guns within the drum are then activated to create a fine mist of coating solution that dries as soon as it reaches the surface of the tablets. As the water or solvent evaporates from the mist, it leaves the solids behind to form a thin film. The secret of film coating is very similar to spray-painting – it is best to spray lightly and evenly so that successive thin coatings are allowed to build up to create a robust dense layer on the surface of the tablet. The time taken to achieve this can range from a few minutes to several hours and is governed by the particular characteristics of the coating material, as well as the process parameters such as drum speed, temperature, pressure and spray rate. Above all these parameters must be carefully controlled for the whole length of the coating process. Disruption of spray rate, for example, will often produce defective tablets. Spraying and distribution The first requirement during the coating process is that the coating suspension must be distributed evenly on the tablet bed. To do this spraying guns are used. Most often these are atomizers that use compressed air to atomize the coating solution or suspension. There are three common atomizer gun types – 2-port, 3-port and 4-port. The simple 2-port gun has one port for the liquid coating solution and the other is for the atomizing air. The only control available for a 2-port gun is the pressure of air on the one port. With a 3-port system, the atomization and spray activation pressures can be controlled independently which allows the spray width to be controlled. With the 4-port gun, three ports are for air and one for liquid, and these allow for the independent control of activation pressure, atomization pressure and spray width. Spray Rate – Film Coating Process